ATHENA STUDY
A trial of a new way to treat pulmonary arterial hypertension
ATHENA is testing tripletestat, an investigational drug given as a daily injection under the skin, added to the PAH medicines you already take. Researchers want to know whether it can ease the pressure in the blood vessels of the lungs.
Enrolling at 10 academic medical centers · Ages 18 to 75 · No cost to take part
The ATHENA investigators and staff, March 2026
90participants
28weeks in the study
5clinic visits
1injection a day
Could ATHENA be right for you?
These are the main things the study team will check. They are not the whole list, and the team can talk any of them through with you.
- ✓You are between 18 and 75 years old
- ✓You have been diagnosed with WHO Group 1 PAH
- ✓You are already on PAH medicine and your dose has been steady for at least 3 months
- ✓You can walk at least 100 metres in six minutes
- ✓You are not pregnant or breastfeeding
What taking part involves
1
Screening
Up to 30 days of tests, including a right heart catheterization
2
Treatment
24 weeks of a once-daily injection you give yourself at home
3
Follow-up
4 more weeks after the injections stop, to see what lasts